吩嗪及其类似物抗肿瘤活性研究进展

Progress of Research on Anti-tumor Activity of Phenazine and Its Analogs

摘要: 天然吩嗪是一类广泛存在于自然界的含氮杂环化合物，来源于土壤和海洋微生物的次生代谢产物，表现出重要的生物学活性。受天然吩嗪活性骨架启发，挖掘并发现具有结构新颖、靶标明确的活性先导化合物，具有重要的药学研究价值。通过对天然来源的吩嗪及其衍生物以及合成类似物的结构、抗肿瘤活性和作用机制的研究进展进行总结，为该类化合物在药物研发中的应用提供参考。

Abstract: Phenazine is a class of nitrogen-containing heterocyclic compounds that are widely found in nature. It is derived from the secondary metabolites of soil and marine microorganisms and exhibits important biological activities. Inspired by the natural phenazine active skeleton, the discovery of active lead compounds with novel structures and clear targets is of great value in pharmaceutical research. Progress of research on the structure, antitumor activity and action mechanism of phenazine natural products and their synthetic analogs is summarized, so as to provide reference for the application of phenazine compounds in drug research and development.