Abstract: Objective To investigate the efficacy of the Yiqi Huoxue Wenshen Lishui Formula combined with acupoint application in treating postoperative urinary retention in patients with benign prostatic hyperplasia (BPH). Methods According to the random number table method, 200 BPH patients with postoperative urinary retention in Lishui City Central Hospital from June 2022 to July 2023 were divided into a control group (n = 100, receiving acupoint application) and an intervention group (n = 100, receiving Yiqi Huoxue Wenshen Lishui Formula combined with acupoint application). The clinical outcomes of the two groups were compared. Results After 7 days of treatment, the total clinical effectiveness rate of the intervention group was higher than that of the control group (P ＜ 0.05). After 3 and 7 days of treatment, the maximum urinary flow rate in the intervention group was higher than that in the control group, while the residual urine volume, symptom-specific scores, and the International Prostate Symptom Score (IPSS) were lower than those in the control group (P ＜ 0.05). Significant between-group, time, and time-by-group interaction effects were observed (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Yiqi Huoxue Wenshen Lishui Formula combined with acupoint application demonstrates significant efficacy and clinical safety in the treatment of postoperative urinary retention in BPH patients.