Abstract: Objective To explore the effectiveness of a pharmaceutical care model integrating a clinical pharmacy workstation and internet-based support for patients with digestive system tumors. Methods In this prospective study, 120 patients with malignant tumors of the digestive system admitted to Haimen District People,s Hospital, Nantong City, from January 2023 to February 2025 were randomly divided into an intervention group or a control group, with 60 patients in each. The control group received routine pharmaceutical care, while the intervention group received pharmaceutical care via the internet plus clinical pharmacy workstation model. Interventions continued until discharge, followed by a 3-month post-discharge follow-up. Medication adherence, quality of life, physical condition, pain level, the incidence of medication errors, adverse drug reactions, and patient satisfaction with pharmaceutical interventions were compared between the two groups. Results At both 1-month and 3-month follow-ups, the intervention group had higher scores on the Morisky medication adherence scale, quality of life questionnaire, and Karnofsky performance status (P ＜ 0.05), and a lower scores on the visual analog scale for pain compared to the control group (P ＜ 0.05); both groups showed improved scores at 3-month follow-up compared to 1-month assessment (P ＜ 0.05). The total incidence of medication errors and adverse drug reactions in the intervention group was lower than that in the control group (P ＜ 0.05), and the overall satisfaction rate with pharmaceutical interventions was higher than that in the control group (P ＜ 0.05). Conclusion The integrated clinical pharmacy workstation and internet-based pharmaceutical care model can effectively improve medication adherence, enhance quality of life, alleviate pain, improve physical status, reduce the incidence of medication errors and adverse drug reactions, and achieve a high patient satisfaction among individuals with digestive system tumors.