Abstract: Objective To explore the preventive effect of enoxaparin intervention timing on venous thromboembolism(VTE) in patients with high-risk traumatic brain injury based on data mining and a Logistic regression model. Methods A retrospective analysis was conducted on 560 high-risk traumatic brain injury patients admitted to Ningbo Sixth Hospital from January 2022 to December 2024. All patients received enoxaparin intervention. According to the intervention time, they were divided into Group A(intervention at 4-5 days after traumatic brain injury, n= 254) and Group B(intervention at 6-7 days after traumatic brain injury, n=306). The baseline data and clinical outcomes of the two groups were compared. Based on whether VTE occurred, the patients were further divided into the VTE group(n= 121) and the non-VTE group(n= 439). The baseline data and examination findings of the two groups were compared. Modeler software was used for data mining, and the feature selection module was employed to screen important indicators. A Logistic regression model was adopted to analyze the influencing factors of VTE in high-risk traumatic brain injury patients, and a composite index was constructed. The predictive value of the composite index for VTE in high-risk traumatic brain injury patients was analyzed using the receiver operating characteristic curve. Results There was no statistically significant difference in bleeding at other sites between the two groups(P> 0.05). The length of hospital stay in Group A was significantly longer than that in Group B(P< 0.05). The incidences of increased intracranial hemorrhage, neurological deterioration, reoperation, and VTE in Group A were significantly higher than those in Group B(P< 0.05). Through data mining with Modeler software, the importance assessment of indicators showed that platelet count(1.0000), muscle strength(1.0000), and central venous catheterization(1.0000) were the most critical factors affecting the incidence of VTE in patients. Body mass index, use of dehydrating agent, duration of bed rest, muscle strength, central venous catheterization, platelet count, and intervention timing were influencing factors for VTE occurrence(P< 0.05). Multivariate Logistic regression analysis revealed that muscle strength ≤ grade 3, the presence of central venous catheterization, and elevated platelet count were independent risk factors for VTE in patients(P< 0.05). The area under the curve of the composite index for predicting VTE occurrence was 0.865(95% CI: 0.825-0.904). Conclusion Premature intervention with enoxaparin may increase the risk of adverse clinical outcomes and VTE in patients. Muscle strength ≤ grade 3, the presence of central venous catheterization, and elevated platelet count are independent risk factors for VTE in patients. The composite index has a high predictive value for VTE occurrence.