Abstract: Bone is an important part of the human body.With the aging of the population and the high incidence of tumors, bone-related diseases have seriously affected the quality of life for patients.Systemic drug administration in the treatment of bone diseases has such disadvantages as poor targeting, serious side-effects and low drug utilization.Bone-targeting drug delivery system effectively overcomes the defects of traditional drug delivery methods in the treatment of bone-related diseases using bone-targeting seekers to functionalize drug carriers, thus improving drug efficacy, reducing costs and reducing the occurrence of adverse reactions.In this paper, the research progress of bone-targeting systems in recent years is summarized with reference to relevant literature, and the application of bone-targeting seekers and nanocarriers in bone-targeting system is reviewed, which provides new ideas for the in-depth study of bone-targeting drug delivery system.