Abstract: Improving drug solubility and dissolution remains an important challenge in the development of pharmaceutical formulations. Supersaturating drug delivery system (SDDS) is one of the effective methods recently developed to improve drug dissolution and absorption. This paper reviewed the application of SDDS in formulation development, the different types of precipitation inhibitors used in the formation of SDDS and their mechanisms, as well as in vitro assays to evaluate supersaturation, providing reference and ideas for the rational design of SDDS for poorly water-soluble drugs.