Abstract: In order to help domestic pharmaceutical companies to fully understand the status of patents on reversible proton pump inhibitors (RPPIs), give directions for the follow-up researches, and enhance market competitiveness, this paper analyzed the application trends, regional distribution and major applicants of RPPIs-related patents as well as the technology life-cycle of RPPIs by using patent intelligence analysis method and retrieved data. Through patent analysis, preliminary information about important applicants and the corresponding geographical distribution can be obtained as a guidance for domestic enterprises to carry out patent strategic layout in advance according to their own R & D plans and market planning, and to expand their market share.