Abstract: The treatment strategies for Parkinson's disease (PD) principally include drug therapy, gene therapy, stem cell therapy and physical neurostimulation, yet all these therapies have certain defects. Nanotechnology, however, stands out with its unique advantages. Nanomaterials function as excellent carriers to deliver drugs and genes, some of which also have neuroprotective effects. Besides, it is promising to utilize nanotechnology in stem cell therapy or neurostimulation. This paper reviews the research and trend of nanotechnology in PD therapy, aiming at a better comprehension of its application so as to deal with the challenges for the treatment of PD.