Abstract: In recent years, individualized therapy has become a key strategy to improve the efficacy and safety of clinical drug therapy. With the continuous development of drug detection technology and clinical application of pharmacogenomics, individualized clinical medication is gradually changing, with more detection methods and varieties of drugs. Based on domestic and foreign literature and information, this article reviews the research and application progress on therapeutic drug monitoring and gene testing technology used in individualized medication, and summarizes the potential new technologies expected to be applied to individualized therapy in the future, and at the same time, raises some bottleneck problems in the current clinical individualized treatment for the reference of future research.