Abstract: Sonodynamic therapy (SDT) is a new strategy for tumor elimination that uses ultrasound to focus sound energy in deep tissues and activate sonosensitizer to produce anti-tumor effect. SDT could overcome some shortcomings of current tumor therapy, such as limited penetration depth. Inorganic nanomaterials-based sonosensitizers have attracted great attention because of their high in vivo stability, tunable physicochemical properties and ease of multifunctionalization. This review summarized recent studies on inorganic nanosonosensitizers in SDT and predicted their future trends of development.