Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely prescribed drugs, but their long-term use can cause many adverse reactions. Compared to conventional formulations, nano-formulations of NSAIDs can improve drug solubility, reduce toxicity, and enhance bioavailability. Furthermore, nano-delivery systems can sustain the release of the loaded NSAIDs and ameliorate the therapeutic efficacy of the drug in the disease model. This review systematically summarizes the recent progress in nano-delivery systems for NSAIDs, including lipid-vesicles nanocarriers, polymer nanocarriers and inorganic nanocarriers.