Abstract: With the progress in the diagnosis and treatment of tumor, the survival time of tumor patients has been prolonged. However, the adverse effects of antitumor treatment such as cardiotoxicity have seriously affected the patients' quality of life and even offset some survival benefits. Therefore, great importance should be attached to the adverse cardiovascular effects of antitumor treatment. Targeted drugs and radiation therapy are both important parts of antitumor therapy. Under the guidance of multidisciplinary therapy, some types of tumors, such as some Her-2 positive breast cancers, usually require combined therapy of targeted drugs and radiation. It has been proved that targeted drugs (such as trastuzumab) or chest radiotherapy alone can cause different types of heart injuries, but the adverse reactions brought by combined therapy of targeted drug and radiation need further investigation. This article discussed the research progress in cardiac safety of the above-mentioned combined antitumor treatment, so as to provide reference for relevant studies.