Abstract: Currently, significant progress has been made in the treatment of primary epithelial tumors. However, the mortality rate of metastatic tumor remains very high and limited progress has been made in its treatment. Studies have shown that IL-4/IL-4R signaling pathway not only plays an essential role in the immune system but also has a strong promoting effect on the survival, proliferation, migration, and invasion of epithelial tumor cells due to its overexpression in several types of epithelial tumor cells. FDA has approved several drugs targeting IL-4/IL-4R signaling pathway for the treatment of asthma. These drugs are currently under the development for cancer treatment. This article reviewed research advances in tumor therapeutic strategies that target IL-4/IL-4R signaling pathway and analyzed some recently developed new therapeutic strategies targeting IL-4/IL-4R pathway, so as to provide reference for the research and development of new drugs.