创新链/学科链/研发链/产业链

新药研发前沿动态 / 医药领域趋势进展

李霞, 李慧, 张志岳. 刺激响应型聚合物在肿瘤免疫治疗方面的研究进展[J]. 药学进展, 2021, 45(5): 325-336.
引用本文: 李霞, 李慧, 张志岳. 刺激响应型聚合物在肿瘤免疫治疗方面的研究进展[J]. 药学进展, 2021, 45(5): 325-336.
LI Xia, LI Hui, ZHANG Zhiyue. Research Progress of Stimuli-responsive Polymers in Tumor Immunotherapy[J]. Progress in Pharmaceutical Sciences, 2021, 45(5): 325-336.
Citation: LI Xia, LI Hui, ZHANG Zhiyue. Research Progress of Stimuli-responsive Polymers in Tumor Immunotherapy[J]. Progress in Pharmaceutical Sciences, 2021, 45(5): 325-336.

刺激响应型聚合物在肿瘤免疫治疗方面的研究进展

Research Progress of Stimuli-responsive Polymers in Tumor Immunotherapy

  • 摘要: 肿瘤微环境刺激响应型聚合物是将肿瘤微环境独特的生理条件作为刺激因子,响应性发生结构或理化性质改变的一系列新型聚合物,具有生物相容性高、稳定性好、机体内可降解代谢、易于修饰等优点。在肿瘤治疗中,免疫治疗法以其突出的治疗效果和长效的免疫记忆而备受关注,将刺激响应型聚合物与肿瘤免疫治疗相结合有望成为肿瘤治疗的新策略。通过对肿瘤部位刺激信号的分类及刺激响应型聚合物的结构类型进行综述,介绍单刺激和多刺激响应聚合物在肿瘤免疫治疗方面的应用,并对其在肿瘤免疫治疗中的优势和挑战进行讨论,以期为刺激响应型聚合物在肿瘤免疫治疗中的应用提供参考。

     

    Abstract: Tumor microenvironment stimuli-responsive polymers are a series of novel polymers that take the unique physiological conditions of tumor microenvironment as stimulation factors and respond to structural or physicochemical changes.They have the advantages of high biocompatibility, good stability, degradable metabolism and easy modification.Immunotherapy has attracted much attention due to its outstanding therapeutic effect and long-term immune memory in tumor treatment.The combination of stimuli-responsive polymers and tumor immunotherapy is expected to become a new strategy for tumor treatment.This paper reviews the classification of stimulation signals in tumor site and the structural types of stimuli-responsive polymers, introduces the application of single and multiple stimuli-responsive polymers in tumor immunotherapy, and also discusses the advantages and challenges of stimuli-responsive polymers in tumor immunotherapy.This review aims to provide reference for the application of stimuli-responsive polymers in tumor immunotherapy.

     

/

返回文章
返回