创新链/学科链/研发链/产业链

新药研发前沿动态 / 医药领域趋势进展

刘姗姗, 林玮, 周剑辉, 廖志勇, 李校堃, 黄志锋. 成纤维细胞生长因子及其在代谢性疾病中的作用与临床应用研究进展[J]. 药学进展, 2019, 43(1): 19-28.
引用本文: 刘姗姗, 林玮, 周剑辉, 廖志勇, 李校堃, 黄志锋. 成纤维细胞生长因子及其在代谢性疾病中的作用与临床应用研究进展[J]. 药学进展, 2019, 43(1): 19-28.
LIU Shanshan, LIN Wei, ZHOU Jianhui, LIAO Zhiyong, LI Xiaokun, HUANG Zhifeng. Research Advances in the Action of Fibroblast Growth Factors in Metabolic Diseases and Its Clinical Application[J]. Progress in Pharmaceutical Sciences, 2019, 43(1): 19-28.
Citation: LIU Shanshan, LIN Wei, ZHOU Jianhui, LIAO Zhiyong, LI Xiaokun, HUANG Zhifeng. Research Advances in the Action of Fibroblast Growth Factors in Metabolic Diseases and Its Clinical Application[J]. Progress in Pharmaceutical Sciences, 2019, 43(1): 19-28.

成纤维细胞生长因子及其在代谢性疾病中的作用与临床应用研究进展

Research Advances in the Action of Fibroblast Growth Factors in Metabolic Diseases and Its Clinical Application

  • 摘要: 成纤维细胞生长因子(fibroblast growth factors,FGFs)是一类广泛存在于生物体内,与细胞生长、增殖和分化密切相关,以旁分泌或内分泌方式调节多种生理病理过程的生长因子。最初发现FGFs在生物体胚胎发育和血管形成方面发挥着重要作用,而随着对其家族成员的不断深入和广泛研究,近来发现其中的内分泌生长因子FGF19、FGF21、FGF23和旁分泌生长因子FGF1对于调控糖脂代谢紊乱引起的代谢性疾病发挥着重要作用,这为多种代谢性疾病的诊治提供了新的思路和方法。综述FGF家族成员在代谢性疾病方面的最新研究进展和临床应用。

     

    Abstract: Fibroblast growth factors (FGFs), a class of growth factors extensively found in organisms, are closely related to cell growth, proliferation and differentiation, and regulate various physiological and pathological processes by paracrine or endocrine effects. FGFs were initially found to play important roles in embryonic development and angiogenesis. With increasingly intensive and extensive studies on the FGF family members, it has been recently found that the endocrine growth factors FGF19, FGF21 and FGF23 and the paracrine growth factor FGF1 in this family play important roles in regulating metabolic diseases caused by glycolipid metabolic disorders, providing new approaches for the diagnosis and treatment of various metabolic diseases. This paper focuses on the latest advances and clinical applications of FGF family members in metabolic diseases.

     

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