创新链/学科链/研发链/产业链

新药研发前沿动态 / 医药领域趋势进展

温雅静, 张灿, 鞠曹云. 辐射响应的化疗药物递送系统用于肿瘤治疗的研究进展[J]. 药学进展, 2018, 42(5): 375-379.
引用本文: 温雅静, 张灿, 鞠曹云. 辐射响应的化疗药物递送系统用于肿瘤治疗的研究进展[J]. 药学进展, 2018, 42(5): 375-379.
WEN Yajing, ZHANG Can, JU Caoyun. Advances in the Research of Radio-responsive Chemotherapeutic Drug Delivery Systems for Anticancer Therapy[J]. Progress in Pharmaceutical Sciences, 2018, 42(5): 375-379.
Citation: WEN Yajing, ZHANG Can, JU Caoyun. Advances in the Research of Radio-responsive Chemotherapeutic Drug Delivery Systems for Anticancer Therapy[J]. Progress in Pharmaceutical Sciences, 2018, 42(5): 375-379.

辐射响应的化疗药物递送系统用于肿瘤治疗的研究进展

Advances in the Research of Radio-responsive Chemotherapeutic Drug Delivery Systems for Anticancer Therapy

  • 摘要: 辐射响应的化疗药物递送系统在增加化疗药物肿瘤靶向性和肿瘤部位可控释放的同时,还能减弱化疗所需辐射射线的强度和频率,因而能更有效地发挥化疗与放疗的协同作用,产生高效、低毒的抗肿瘤作用,对于肿瘤的治疗具有重要意义。综述近年来针对不同放疗辐射源(包括X-射线、γ-射线和长波长光等)响应的化疗药物递送系统用于肿瘤治疗的研究进展,为辐射响应的化疗药物递送系统的设计和应用提供参考。

     

    Abstract: The radio-responsive chemotherapeutic drug delivery system can increase the tumor-targeting ability and controllable release of chemotherapeutic drugs as well as reduce the intensity and frequency of radiation needed by chemotherapy. It enhances the synergistic action of chemotherapy and radiotherapy with maximum efficacy and minimal side effects, playing an important role in cancer treatment. In this paper, research advances in the application of radio-responsive chemotherapeutic drug delivery systems with different sources of radiation (X-ray, γ-ray and long-wavelength visible light) in cancer treatment were reviewed, which supposed to provide references for the design and application of chemotherapeutic drug delivery systems.

     

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