糖相关分子在疾病中作用的研究进展

Advances in Research on the Role of Sacchariderelated Molecules in Diseases

摘要: 生命体中的糖链及相关分子如糖基转移酶、糖苷水解酶和糖链结合蛋白等与健康和疾病密切相关。蛋白质和脂类糖基化是细胞内存在的重要的翻译后修饰过程，由糖基转移酶和糖苷水解酶协同完成。其过程与感染、肿瘤和其他疾病的相关性正日益得到关注和重视。研究显示在癌症的进展过程中，糖基化相关基因表达水平有显著的变化，聚糖的生物合成通路为癌症、感染及遗传性疾病的诊治提供了新的思路。综述了糖相关分子在各类疾病中作用的研究进展。

Abstract: Sugar chains and related molecules (including glycan transferase, glycoside hydrolase and glycan binding protein) in living organisms are closely related to health and diseases. The glycosylation of protein and lipid is an important post-translational modification process in cells, which is completed by glycosyltransferase and glycoside hydrolase. The relevance of its process to infections, tumors and other diseases is attracting more and more attention. Studies have shown that in the progress of cancer, the expression levels of glycosylation-related genes have changed significantly. The glycan biosynthesis pathways provide new insights for the diagnosis and treatment of cancer, infection and genetic diseases. This review summarizes the advances in research on the role of saccharide-related molecules in diseases.