Abstract: As a β-type coronavirus, SARS-CoV-2 uses angiotensin converting enzyme 2 (ACE2) as the receptor to invade the host cell like SARS-CoV. Clinically, patients mainly showed respiratory infection and lung injury. Currently, SARS-CoV is commonly used as a comparison to study SARS-CoV-2. This paper introduces the classification, structure and life cycle of coronavirus and the role of ACE2 in SARS-CoV, and summarizes the relevant research progress and pharmacokinetic profiles of possible therapeutic drugs of SARSCoV-2, so as to provide reference for better understanding of the SARS-CoV-2 evolution process and R&D of the related drugs.