创新链/学科链/研发链/产业链

新药研发前沿动态 / 医药领域趋势进展

张志仁. 免疫检查点抑制剂及其心血管不良反应研究进展[J]. 药学进展, 2018, 42(7): 492-499.
引用本文: 张志仁. 免疫检查点抑制剂及其心血管不良反应研究进展[J]. 药学进展, 2018, 42(7): 492-499.
ZHANG Zhiren. Research Progress in Cardiovascular Adverse Effects of Immune Checkpoint Inhibitors[J]. Progress in Pharmaceutical Sciences, 2018, 42(7): 492-499.
Citation: ZHANG Zhiren. Research Progress in Cardiovascular Adverse Effects of Immune Checkpoint Inhibitors[J]. Progress in Pharmaceutical Sciences, 2018, 42(7): 492-499.

免疫检查点抑制剂及其心血管不良反应研究进展

Research Progress in Cardiovascular Adverse Effects of Immune Checkpoint Inhibitors

  • 摘要: 免疫检查点抑制剂作为抗肿瘤治疗里程碑式的进展,可用于多种肿瘤的治疗,受到广泛关注。随着其临床应用日益增多,由其引起的多种脏器不良反应亦逐渐凸显,尤其是心血管不良反应中的心肌炎,具有高致死率的特点,应引起重视,治疗方案包括激素和免疫抑制剂,但对接受这类药物的患者需要常规监测心血管不良反应。

     

    Abstract: Being widely used for the treatment of many types of cancers, immune checkpoint inhibitors have received extensive attention as a landmark in the development of anti-cancer therapy. With their more extensive clinical application, organ specific adverse reactions have become increasingly prominent, especially myocarditis. As one of the cardiovascular adverse effects, myocarditis has a high fatality rate and should be brought to the forefront. Glucocorticoid and immunosuppressants are the mainstays of current treatment. Routine monitoring of cardiovascular adverse effects is essential for patients receiving treatment with immune checkpoint inhibitors.

     

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