创新链/学科链/研发链/产业链

新药研发前沿动态 / 医药领域趋势进展

苏洁, 成扶雨, 卜军. 生物钟核受体RORα和REV-ERBα在血管病理生理中的作用[J]. 药学进展, 2020, 44(12): 906-916.
引用本文: 苏洁, 成扶雨, 卜军. 生物钟核受体RORα和REV-ERBα在血管病理生理中的作用[J]. 药学进展, 2020, 44(12): 906-916.
SU Jie, CHENG Fuyu, PU Jun. Roles of Circadian Nuclear Receptor RORα and REV-ERBα in Vascular Pathophysiology[J]. Progress in Pharmaceutical Sciences, 2020, 44(12): 906-916.
Citation: SU Jie, CHENG Fuyu, PU Jun. Roles of Circadian Nuclear Receptor RORα and REV-ERBα in Vascular Pathophysiology[J]. Progress in Pharmaceutical Sciences, 2020, 44(12): 906-916.

生物钟核受体RORα和REV-ERBα在血管病理生理中的作用

Roles of Circadian Nuclear Receptor RORα and REV-ERBα in Vascular Pathophysiology

  • 摘要: 人体的生理活动受到生物钟系统内时钟基因的调控。生物钟核受体RORα和REV-ERBα是人体生物钟系统的重要组成部分,二者在维持机体生物节律中发挥着重要作用。RORα和REV-ERBα亦参与调节糖代谢、脂质代谢、血管炎症反应和纤溶蛋白降解等病理生理过程。大量研究表明,异常的昼夜节律是血管功能紊乱的独立危险因素。围绕生物钟核受体RORα和REV-ERBα在生物节律和血管稳态调节中的作用,对RORα和REV-ERBα在血管病理生理过程中关键作用的最新研究进展进行综述。

     

    Abstract: Human physiological activities follow regular circadian rhythms which are under the control of clock genes. The nuclear receptors RORα and REV-ERBα are core components of the clock machinery, playing an important role in keeping proper timing of the clock. Furthermore, RORα and REV-ERBα regulate glucose metabolism, lipid metabolism, vascular inflammation, and fibrinolysis. A large number of studies have shown that abnormal circadian rhythm is an independent risk factor for vascular dysfunction. In this paper, we focus on the roles of RORα and REV-ERBα in circadian rhythm and vascular homeostasis, and review the latest research progress on the roles of RORα and REV-ERBα in the vascular pathophysiological function.

     

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