创新链/学科链/研发链/产业链

新药研发前沿动态 / 医药领域趋势进展

王谊扬, 刘阳, 袁胜涛, 孙立. 逆转肿瘤微环境异常pH梯度的抗癌新策略[J]. 药学进展, 2019, 43(7): 544-550.
引用本文: 王谊扬, 刘阳, 袁胜涛, 孙立. 逆转肿瘤微环境异常pH梯度的抗癌新策略[J]. 药学进展, 2019, 43(7): 544-550.
WANG Yiyang, LIU Yang, YUAN Shengtao, SUN Li. New Anti-cancer Strategies to Reverse the Abnormal pH Gradient of Tumor Microenvironment[J]. Progress in Pharmaceutical Sciences, 2019, 43(7): 544-550.
Citation: WANG Yiyang, LIU Yang, YUAN Shengtao, SUN Li. New Anti-cancer Strategies to Reverse the Abnormal pH Gradient of Tumor Microenvironment[J]. Progress in Pharmaceutical Sciences, 2019, 43(7): 544-550.

逆转肿瘤微环境异常pH梯度的抗癌新策略

New Anti-cancer Strategies to Reverse the Abnormal pH Gradient of Tumor Microenvironment

  • 摘要: 外酸化与内碱化的现象普遍存在于不同类型的恶性肿瘤中。这种微环境异常pH梯度的形成与肿瘤细胞的组织结构和代谢特点密切相关。微环境负pH梯度的维持与一些离子交换蛋白,如Na+/H+交换体-1(NHE-1)、空泡质子泵(V-ATPase)、HCO3-转运体等息息相关。碳酸酐酶(CA)对肿瘤细胞内外pH梯度的维持也有着重要意义。综述肿瘤微环境失调pH的成因、异常的微环境pH对肿瘤生长发展的影响以及一些逆转微环境异常pH梯度的治疗策略,为相关药物的开发提供思路。

     

    Abstract: External acidification and internal alkalization are common in different types of malignant tumors. The formation of this abnormal microenvironment of pH gradient is closely related to the tissue structure and metabolic characteristics of tumor cells. The maintenance of the negative pH gradient in the microenvironment is closely related to some ion exchange proteins such as Na+/H+ exchanger-1 (NHE-1), vacuolar proton pump (V-ATPase), HCO3- transporter and so on. Carbonic anhydrase (CA) also plays an important role for the maintenance of the pH gradient in the microenvironment. This article reviews the causes of abnormal pH of tumor and the influence on its growth and progression, and some treatment strategies to reverse the abnormal pH gradient of tumor microenvironment, so as to provide some ideas for the development of related drugs.

     

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