创新链/学科链/研发链/产业链

新药研发前沿动态 / 医药领域趋势进展

蒙钟经, 丁选胜. 何首乌的入血成分、药动学及肝毒性代谢组学研究进展[J]. 药学进展, 2019, 43(5): 379-383.
引用本文: 蒙钟经, 丁选胜. 何首乌的入血成分、药动学及肝毒性代谢组学研究进展[J]. 药学进展, 2019, 43(5): 379-383.
MENG Zhongjing, DING Xuansheng. Recent Advances in the Study of Polygoni Multiflori Radix: Its Absorbed Components in Rat Blood, Pharmacokinetics and Metalobomic Study of Hepatotoxicity[J]. Progress in Pharmaceutical Sciences, 2019, 43(5): 379-383.
Citation: MENG Zhongjing, DING Xuansheng. Recent Advances in the Study of Polygoni Multiflori Radix: Its Absorbed Components in Rat Blood, Pharmacokinetics and Metalobomic Study of Hepatotoxicity[J]. Progress in Pharmaceutical Sciences, 2019, 43(5): 379-383.

何首乌的入血成分、药动学及肝毒性代谢组学研究进展

Recent Advances in the Study of Polygoni Multiflori Radix: Its Absorbed Components in Rat Blood, Pharmacokinetics and Metalobomic Study of Hepatotoxicity

  • 摘要: 中药何首乌为蓼科植物何首乌Polygonum multiflorum Thunb.的干燥块根,是一种常用的补益中药,并兼有药食同源的应用基础。但近年来,何首乌及其制剂导致药源性肝损伤的报道日益增多,其安全性问题已成为人们关注的焦点。基于此,对近年来何首乌入血成分、药动学及肝毒性代谢组学的研究进展进行综述,以期为何首乌在临床上安全、合理应用提供参考。

     

    Abstract: Polygoni multiflori radix is the dried root tuber of Polygonum multiflorum Thunb. (Fam. Polygonaceae). It belongs to the category of Chinese tonic herbs and widely utilized both as food and medicine. In recent years, there have been increased reports on hepatic lesions caused by polygoni multiflori radix and its preparation, raising concerns about the safety issues of polygoni multiflori radix. This article summarized the recent advances in the absorbed components of polygoni multiflori radix in rat blood, its pharmacokinetics, and metabolomic study of its hepatotoxicity, so as to provide reference for its safe and rational clinical application.

     

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