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新药研发前沿动态 / 医药领域趋势进展

刘梦琪, 臧奕, 李佳. 肝脏巨噬细胞在组织稳态和肝脏疾病中的功能探讨[J]. 药学进展, 2018, 42(10): 723-736.
引用本文: 刘梦琪, 臧奕, 李佳. 肝脏巨噬细胞在组织稳态和肝脏疾病中的功能探讨[J]. 药学进展, 2018, 42(10): 723-736.
LIU Mengqi, ZANG Yi, LI Jia. The Roles of Hepatic Macrophages in Tissue Homeostasis and Liver Diseases[J]. Progress in Pharmaceutical Sciences, 2018, 42(10): 723-736.
Citation: LIU Mengqi, ZANG Yi, LI Jia. The Roles of Hepatic Macrophages in Tissue Homeostasis and Liver Diseases[J]. Progress in Pharmaceutical Sciences, 2018, 42(10): 723-736.

肝脏巨噬细胞在组织稳态和肝脏疾病中的功能探讨

The Roles of Hepatic Macrophages in Tissue Homeostasis and Liver Diseases

  • 摘要: 巨噬细胞在肝脏中扮演关键角色,对于维持组织稳态和确保机体对肝损伤的迅速应答至关重要。对肝脏巨噬细胞的异质亚群划分,有利于更加全面深入地理解其功能。库普弗细胞是一种驻留在肝脏中的、可自我维持的巨噬细胞群体,区别于单核细胞衍生的巨噬细胞,后者仅在损伤发生时迅速聚集至肝脏。特定的环境信号决定肝脏巨噬细胞的进一步极化表型和功能。不同亚群的肝脏巨噬细胞既可以促进肝脏在损伤或感染后组织完整性的恢复,也会导致如肝炎、纤维化、癌症等疾病病程的加剧。重点介绍近年来有关肝脏巨噬细胞的起源、分类和功能的新发现,并探讨它们在肝脏生理和病理状态下的不同功能,以期为肝脏巨噬细胞的深入研究提供理论基础。

     

    Abstract: Macrophages play essential roles in maintaining tissue homeostasis and ensuring a rapid response to liver damage. Dividing hepatic macrophages into heterogeneous subpopulations is conducive to a more comprehensive understanding of their functions. Kupffer cells are self-sustainable microphage populations that reside in the liver and are usually distinguished from monocyte-derived macrophages which only rapidly accumulate in damaged liver. Specific environmental signals determine the further polarization and function of liver macrophages. Various subpopulations of hepatic macrophages can either protect liver integrity after injury or infection or lead to exacerbation of hepatitis, fibrosis and cancer. This article focused on the recent advances in the origin, classification and function of liver macrophages, and discussed their distinct roles in liver physiology and pathology, so as to provide a theoretical basis for further investigation of liver macrophages.

     

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