创新链/学科链/研发链/产业链

新药研发前沿动态 / 医药领域趋势进展

王慧英, 王锐, 杨华, 李萍. 基于质谱技术的药物代谢产物鉴定策略进展[J]. 药学进展, 2018, 42(3): 193-200.
引用本文: 王慧英, 王锐, 杨华, 李萍. 基于质谱技术的药物代谢产物鉴定策略进展[J]. 药学进展, 2018, 42(3): 193-200.
WANG Huiying, WANG Rui, YANG Hua, LI Ping. Recent Advances in Mass Spectrometry-based Identification of Drug Metabolites[J]. Progress in Pharmaceutical Sciences, 2018, 42(3): 193-200.
Citation: WANG Huiying, WANG Rui, YANG Hua, LI Ping. Recent Advances in Mass Spectrometry-based Identification of Drug Metabolites[J]. Progress in Pharmaceutical Sciences, 2018, 42(3): 193-200.

基于质谱技术的药物代谢产物鉴定策略进展

Recent Advances in Mass Spectrometry-based Identification of Drug Metabolites

  • 摘要: 药物代谢产物鉴定是药物代谢研究的重要环节,也是药理药效研究的物质基础。在药物代谢产物分析检测中,质谱技术因具有适用范围广、灵敏度高等优势而成为药物代谢产物的主要检测手段。基于质谱技术的药物代谢产物鉴定常用的方法有标准品比对、文献及数据库比对、质谱图谱解析、放射性同位素标记以及计算机辅助鉴定。综述近年来常用于药物代谢产物鉴定的质谱鉴定方法研究进展,以期为药物代谢产物研究提供参考。

     

    Abstract: Identification of drug metabolites is an important part of drug metabolism research and the material basis of pharmacology and pharmacodynamics research. Mass spectrometry is a major detection method for drug metabolites due to its high sensitivity and extensive application. In general, the methods of drug metabolites identification include reference standards comparison, literature and database matching, comprehensive spectrometry analysis, radioisotope labeling and computer-assisted structural elucidation. In this paper, recent advances in these methods were summarized in order to provide reference for the identification of drug metabolites.

     

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