创新链/学科链/研发链/产业链

新药研发前沿动态 / 医药领域趋势进展

朱良瀚, 崔芷莹, 朱启华, 徐云根. 阿片受体激动剂研究进展[J]. 药学进展, 2018, 42(7): 537-543.
引用本文: 朱良瀚, 崔芷莹, 朱启华, 徐云根. 阿片受体激动剂研究进展[J]. 药学进展, 2018, 42(7): 537-543.
ZHU Lianghan, CUI Zhiying, ZHU Qihua, XU Yungen. Advances in Research on Opioid Receptor Agonists[J]. Progress in Pharmaceutical Sciences, 2018, 42(7): 537-543.
Citation: ZHU Lianghan, CUI Zhiying, ZHU Qihua, XU Yungen. Advances in Research on Opioid Receptor Agonists[J]. Progress in Pharmaceutical Sciences, 2018, 42(7): 537-543.

阿片受体激动剂研究进展

Advances in Research on Opioid Receptor Agonists

  • 摘要: 疼痛是机体在受到伤害时的一种反馈而产生令人不快的主观感受,起到警示机体存在实质性或潜在的组织损伤的作用。治疗和缓解疼痛的主要药物是阿片受体激动剂,而传统的阿片受体激动剂存在阿片样副作用(包括成瘾性、耐受性、呼吸抑制性等),从而限制其广泛应用。科研工作者寻找出许多规避副作用的策略,着重介绍在μ-阿片受体激动剂的设计和应用中消除阿片样副作用的传统策略和新型策略,简要介绍κ-阿片受体激动剂的最新研究进展,以期为镇痛药的研发及临床治疗提供新的思路。

     

    Abstract: Pain is a kind of feedback of body injury which produces unpleasant subjective feelings, alerting the individual of actual or potential tissue damage. The mainstream drugs for the treatment and relief of pain are opioid receptor agonists. However, opioid-like side effects (addiction, tolerance, respiratory depression, etc.) of traditional opioid agonists limit their widespread use. Researchers have developed many effective strategies to avoid the side effects. In this article, the traditional and novel strategies to eliminate opioid side effects during the design and application of μ-opioid receptor agonists were highlighted, and the recent research progress of κ-opioid receptor agonists was briefly introduced, so as to provide new ideas for the development of analgesics and clinical treatment of pain.

     

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