Abstract: Clinical studies have suggested that early intensive control of hyperglycaemia could ameliorate high glucose-induced "metabolic memory", and decrease the risk of diabetic vascular complications. There is growing evidence that metabolic memory may be related to non-enzymatic glycosylation of proteins, epigenetic changes, oxidative stress and chronic inflammation. However, there are few reports on strategies for pharmacotherapy of high glucose-induced metabolism memory. This paper reviewed the therapeutic drugs and therapeutic strategies for alleviating high glucose-induced metabolic memory from the above mentioned four aspects as well as potential therapeutic targets, so as to provide reference for related researches.