创新链/学科链/研发链/产业链

新药研发前沿动态 / 医药领域趋势进展

滕云飞, 苏东明, 梁秀彬. 蛋白质糖基化与衰老相关性疾病关系的研究进展[J]. 药学进展, 2021, 45(11): 818-826.
引用本文: 滕云飞, 苏东明, 梁秀彬. 蛋白质糖基化与衰老相关性疾病关系的研究进展[J]. 药学进展, 2021, 45(11): 818-826.
TENG Yunfei, SU Dongming, LIANG Xiubin. Progress of Research on the Relationship between Protein Glycosylation and Aging-related Diseases[J]. Progress in Pharmaceutical Sciences, 2021, 45(11): 818-826.
Citation: TENG Yunfei, SU Dongming, LIANG Xiubin. Progress of Research on the Relationship between Protein Glycosylation and Aging-related Diseases[J]. Progress in Pharmaceutical Sciences, 2021, 45(11): 818-826.

蛋白质糖基化与衰老相关性疾病关系的研究进展

Progress of Research on the Relationship between Protein Glycosylation and Aging-related Diseases

  • 摘要: 人体在衰老过程中,体内的分子、细胞和器官损伤的积累会诱发一系列疾病,例如心血管疾病、代谢类疾病、神经系统疾病等。近年来,随着老年人口的不断增加,因衰老带来的问题日渐严重,亟需发现能够预测、诊断和随访衰老过程的生物标志物。研究表明,蛋白质表面的聚糖具有充当这一生物标志物的可能性。蛋白质的糖基化水平反映了细胞内和细胞间的生物学过程的实时状态,通过观察这些变化可以为不同疾病的诊断和预后观察筛选出潜在的生物标志物。对衰老以及与衰老相关的疾病中的糖组学变化情况进行综述,旨在为疾病的机制研究及诊断和治疗提供思路。

     

    Abstract: The accumulation of molecular, cellular and organ damage in the process of aging can induce various diseases, such as cardiovascular, metabolic and nervous system diseases. With the continuous increase of elderly population in recent years, the problems caused by aging are becoming more and more serious, so biomarkers are needed to predict, diagnose and follow up the aging process.Studies have shown that polysaccharides on the surface of proteins are likely to act as the biomarkers. The glycosylation level of protein reflects the real-time state of intracellular and intercellular biological processes, which can provide potential biomarkers for diagnosis and prognosis of multifactor diseases by observing changes in glycosylation level. This article reviews the changes of glycosomics in aging and aging-related diseases, so as to provide ideas for the research on the mechanisms as well as the diagnosis and treatment of diseases.

     

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