Abstract: Hydrogen sulfide (H₂S), together with nitric oxide (NO) and carbon monoxide (CO), belongs to the gasotransmitter family and plays important roles in mammals as a signaling molecule. Many studies have shown the various therapeutic effects of H₂S, which include vasodilation, cardioprotection, anti-inflammation and anti-oxidation. One major challenge in the development of H₂S-based therapeutics is its delivery. This paper reviews the various recent H₂S delivery strategies in the context of eventual developability for guiding future research in the development of H₂S-based therapeutics.