Abstract: The SARS-CoV-2 pandemic has brought tremendous impact on global public health security and economy since its outbreak. At present, the global anti-epidemic efforts have achieved phased results, and the SARS-CoV-2 epidemic no longer constitutes "a Public Health Emergency of International Concern", but this does not mean that the SARS-CoV-2 epidemic has ended. The research and development of COVID-19 therapeutic drugs should not only continue, but also need to be further explored. In this article, the infection mechanism of SARS-CoV-2 has been briefly introduced, and the research progress of COVID-19 therapeutic drugs based on virus and host cell targets has also been reviewed.