临床药物个体化治疗技术体系研究进展

Advances of Research on Technologies for Individualized Treatment in Clinical Drug Therapy

摘要: 临床药物个体化治疗是精准医疗的重要组成部分，代表现代医学的最新发展趋势，旨在保障患者用药安全、有效和经济。近年来随着分子生物学、基因组学和生物信息学技术的进步，临床药物个体化治疗已开始利用药物基因组学、治疗药物监测等技术获得一些良好的治疗效果，新兴的类器官技术也在肿瘤药物治疗领域崭露头角。综述临床药物个体化治疗技术体系研究进展，以期为相关研究和治疗提供参考。

Abstract: As the core of precision medicine, individualized treatment in clinical drug therapy represents the latest trend of development in contemporary medicine, aiming to ensure the effectiveness, safety and economy of medication. In recent years, with the development of molecular biology, genomics and bioinformatics, pharmacogenomics and therapeutic drug monitoring have helped to afford individualized therapeutic regimen. Significantly, organoid technique has emerged as a new and powerful approach. This article reviews advances of the above-mentioned technologies and their application in personalized pharmacotherapy.