Abstract: People with immune dysfunction are a special group, including patients with innate and acquired immune deficiencies, autoimmune diseases and allergic diseases. Such people are more susceptible to the COVID-19 infection, which is more likely to become severe with higher rate of fatality. Therefore, except for the absolute contraindications, they should receive vaccination against COVID-19. The COVID-19 vaccines available on the market in China include inactivated vaccine, recombinant subunit protein vaccine and adenovirus vector vaccine, each with its own advantages and disadvantages. However, based on the limited evidence-based medical data, the inactivated vaccine has better performance in terms of immune protection and adverse reactions and therefore seems worthy of preferential recommendation at present. Before receiving the vaccine, the patient with immune dysfunction should receive separate or group evaluation from multidisciplinary doctors, with special attention to several issues during the vaccination process, including continued preventive measures, continued treatment of basic diseases, and close monitoring of adverse reactions after inoculation. In addition, staff or family members for clinical care of the immune dysfunction patient should be vaccinated.