Recent Advances in Inhibitors of Histone Acetyltransferase p300/CBP

The p300/CBP family consisting of the highly homologous adenovirus E1A-associated 300 kDa protein (p300) and CREB (cAMP responsive element binding protein) binding protein (CBP) is one of the major members of the histone acetyltransferases families (HAT). Acting as a very important coactivator that can regulate the functions of key transcription regulatory factors, p300/CBP is involved in cell cycle progression as well as cell growth, differentiation and development. Since p300/CBP is also closely related to a variety of tumors, it emerges as a promising target for tumor therapy. This paper reviewed the research progress of p300/CBP inhibitors in order to provide reference for the development of novel selective p300/CBP inhibitors.