Abstract: Prostate cancer (PCa), a common malignancy in men worldwide, has a high rate of morbidity and mortality in China. With their confirmed structures and rich sources, traditional Chinese medicine (TCM) monomers have their special advantages for developing anti-PCa drugs. This study reviews the action mechanisms of TCM monomers in the treatment of PCa from androgen receptor (AR) dependence and AR independence, so as to provide some reference for the exploration of specific PCa therapeutic regimens using TCM and useful information for the development of novel drugs treating PCa.