Abstract: Drug-induced liver injury during pregnancy (DILI), one of the key causes of acute liver failure and even death in pregnant women, seriously impairs maternal and infant outcomes. Nowadays, DILI has received increasing clinical attention due to its uncommon yet serious consequences. The management of DILI faces great challenges due to the lack of studies on the safety of medication during pregnancy, the complex influencing factors, and the difficulty in diagnosis. In this article, the epidemiology, types, influencing factors, common drugs, clinical diagnosis and management of DILI are reviewed to provide a valuable basis for clinical practice.