Abstract: Autism spectrum disorder (ASD) is also known as autism. As the prevalence of ASD increases year by year, it poses a heavy burden on families and society. The pathogenesis of ASD is still unclear and there is still no effective therapy for it so far. A line of reports have shown different causes of ASD, including genetic factors, immune factors, environmental factors and so on, among which the immune factors play an important role in neural development and synaptic formation. Many studies have shown various immune abnormalities in ASD, such as the emergence of autoantibodies, abnormal immune cells and cytokines, and abnormal neuro-immune signal transmission, etc., which are usually related to the main symptoms of ASD patients. This article reviews the latest progress of drug therapy and immunotherapy for ASD, in an attempt to provide some insight for the treatment of ASD.