Abstract: Proteins are the core building blocks of living systems, and a precise understanding of their structure and function is essential for revealing biological processes and drug development.With the rapid development of artificial intelligence technology, its application in the field of protein engineering, especially in the prediction of protein attribute, has become a hot research topic.This article reviews the latest developments in the field of biomedical engineering, with focus on the important role of artificial intelligence technology in protein engineering, and highlights the innovative achievements of artificial intelligence algorithms in predicting protein attribute, with deep discussion on its potential application and challenges in the field.