Abstract: The adrenal gland, an endocrine organ, can synthesize steroid hormones, catecholamine hormones and other effective substances to help maintain the homeostasis of neuro-immune-endocrine system.Traditional Chinese medicines (TCMs) have garnered widespread attention due to their characteristics, including multi-component, multi-target, and multi-pathway.They offer unique advantages in treating endocrine system diseases, metabolic disorders and other diseases.However, more research is needed to fully understand the effects of TCMs on the adrenal gland.This article has reviewed the regulation effects of TCMs on adrenal morphology and function, and the research progress of TCMs in the treatment of rheumatoid arthritis and depression by regulating the adrenal function, aiming to provide references for further enriching the research on the TCMs and endocrine.