Abstract: Influenza viruses cause seasonal influenza and influenza pandemics, which pose a serious threat to human health. Antiinfluenza virus drugs are crucial in controlling the outbreak and spread of influenza. However, there are currently limited options of antiinfluenza virus drugs in clinical practice. Additionally, influenza viruses are highly prone to mutation, leading to an increase in drugresistant virus strains. Therefore, it is necessary to develop new drugs that can inhibit drug-resistant strains of the virus with novel antiviral mechanisms. This paper summarizes the research progress of anti-influenza virus drugs that target influenza virus components. It focuses on the types of drugs, their mechanisms of action, the occurrence of drug resistance, the transformation of old drugs and the development of new target drugs for drug resistance targets, as well as the future development of anti-influenza virus drugs, with the aim of providing some reference for therapy and the research and development of drugs against influenza virus infections.