丙型肝炎病毒非结构蛋白5B聚合酶抑制剂的研究进展

Progress of Hepatitis C Virus Non-structural Protein 5B Polymerase Inhibitors

摘要: 丙型肝炎病毒（hepatitis C virus，HCV）感染是全球范围内的健康挑战。该病毒的非结构蛋白 5B（non-structuralprotein 5B，NS5B）聚合酶对其 RNA 的复制起到了关键作用，是抗 HCV 药物研究的关键靶标。近年来，针对 HCV NS5B 聚合酶抑制剂的研究取得了显著进展。通过对 HCV NS5B 聚合酶的结构特性和功能进行介绍，揭示其在病毒复制过程中的核心作用，同时，以 NS5B 聚合酶为靶标综述了核苷类和非核苷类 2 大类抗 HCV 抑制剂的研究进展。相关研究为抗 HCV 抑制剂的进一步研发提供了重要参考和思路。

Abstract: Hepatitis C virus (HCV) infection is a worldwide health challenge. The non-structural protein 5B (NS5B) polymerase of the virus plays a key role in its RNA replication and is a key target for anti-HCV drug research. In recent years, studies on HCV NS5B polymerase inhibitors have made remarkable progress. This article introduces the structural properties and functions of HCV NS5B polymerase, reveals its central role in the process of viral replication, and reviews the research progress of two major classes of anti-HCV inhibitors, nucleoside and non-nucleoside, using NS5B polymerase as the target. The relevant studies provide some important reference and ideas for the further development of anti-HCV inhibitors.