Abstract: The active components of traditional Chinese medicine (TCM) often exhibit low water solubility and poor stability, which results in poor druggability and limited clinical application. As a commonly used crystal engineering strategy, co-crystallization shows great potential in improving the physicochemical properties of TCM and enhancing their druggability. This review gives a comprehensive introduction to the development and application of pharmaceutical cocrystals in TCM and explores the potential and limitations of cocrystallization in improving the druggability of TCM active components, aiming to provide useful information for co-crystallization research and drug development of TCM.