创新链/学科链/研发链/产业链

新药研发前沿动态 / 医药领域趋势进展

皮肤生理药代动力学模型研究进展

Research Progress of Dermal Physiologicallybased Pharmacokinetic Models

  • 摘要: 皮肤局部给药后,药物在皮肤内的吸收、分布、代谢和排泄等药代动力学过程复杂,难以准确监测和研究。而生理药代动力学(physiologically-based pharmacokinetics,PBPK)建模和模拟技术为皮肤药代动力学(dermal pharmacokinetics,DPK)研究提供了新的研究思路和方法。皮肤PBPK模型是利用体外皮肤渗透实验、药物理化性质、制剂学属性、体内动物实验以及人体皮肤组织病理生理特征等数据构建的一种基于生理机制的定量药理学模型,该模型可表征药物活性成分在皮肤各层中的分布及处置过程,用于预测药物在皮肤的药代动力学特征及剂量-暴露-效应关系,从而指导临床合理用药。综述了皮肤PBPK模型的研究进展。

     

    Abstract: After topical application, the pharmacokinetic processes of drug absorption, distribution, metabolism, and excretion within the skin are complex and challenging to accurately monitor and study. Physiologically-based pharmacokinetic (PBPK) modeling and simulation technology provides new research insights and methods for dermal pharmacokinetics (DPK) research. Dermal PBPK models are quantitative pharmacology models based on physiological mechanisms, constructed using data from in vitro skin permeation experiments, physicochemical properties of drugs, formulation attributes, in vivo animal experiments, and histopathological and physiological characteristics of human skin. These models characterize the distribution and disposition of active pharmaceutical ingredients across distinct skin layers, enabling the prediction of dermal pharmacokinetic profiles and the dose-exposure-response relationships, thereby guiding rational clinical drug use. This article reviews the research progress of the dermal PBPK models.

     

/

返回文章
返回