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新药研发前沿动态 / 医药领域趋势进展

糖酵解重塑在阿尔茨海默病中的作用与防治靶点研究

The Roles of Glycolytic Reprogramming in Alzheimer’s Disease and Its Prevention and Treatment Targets

  • 摘要: 阿尔茨海默病(Alzheimer,s disease,AD)是当代社会最严峻的医疗难题之一。大脑是能量需求最高的器官,拥有最活跃的糖代谢过程。大脑组织内的神经胶质细胞与神经元之间通过突触产生广泛的联系,在正常生理条件下,星形胶质细胞通过有氧糖酵解产生乳酸,给神经元提供能源分子,乳酸同时也是一种信号分子,调节突触的可塑性。但在AD病变条件下,小胶质细胞和神经元内的糖酵解过程亦会显著上调并产生大量乳酸,由此导致一系列的炎症反应,并诱发AD。因此,糖酵解途径中的相关酶和通路有望成为AD的防治靶点。

     

    Abstract: Alzheimer’s disease (AD) is one of the most serious medical problems in modern society. The brain is the organ with the highest energy requirements and the most active processes of carbohydrate metabolism. The glial cells and neurons in the brain tissue have extensive connections through synapses. Under normal physiological conditions, astrocytes produce lactic acid through aerobic glycolysis to provide energy molecules to neurons. Lactic acid is also a signaling molecule to regulate the plasticity of synapses. However, under the condition of AD, the glycolytic process in microglia and neurons will be significantly up-regulated and produce a large amount of lactic acid, which will lead to a series of inflammatory reactions and induce AD. Therefore, the related enzymes and pathways in the glycolytic pathway are expected to be the targets for the prevention and treatment of AD.

     

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