Abstract: Fibroblast activation protein ( FAP ) has become a potential target in the field of tumor therapy in recent years due to its specific high expression in cancer-associated fibroblast(CAF). In recent years, radiopharmaceuticals targeting FAP have received extensive attention due to their specificity and potential therapeutic effects. These targeted drugs have great potential in the diagnosis and treatment of tumors, especially in the precise diagnosis and treatment of solid tumors. Studies have shown that these drugs can specifically deliver radionuclides to CAF in the tumor microenvironment, thereby achieving precise treatment of tumors. By summarizing the types of radiopharmaceuticals targeting FAP and their mechanism of action, and analyzing the research progress of FAP in tumor diagnosis and treatment, this paper aims to provide some reference for future development of FAP-targeted radiopharmaceuticals.