创新链/学科链/研发链/产业链

新药研发前沿动态 / 医药领域趋势进展

通督益脑化痰汤联合头项针治疗脑卒中后吞咽障碍的随机对照研究

A Randomized Controlled Study of Tongdu Yinao Huatan Decoction Combined with Scalp and Neck Acupuncture in the Treatment of Dysphagia after Stroke

  • 摘要: 目的 探讨通督益脑化痰汤、头项针联合治疗脑卒中后吞咽障碍的疗效。方法 选择2023年1月至2024年7月金华市人民医院接诊的脑卒中后吞咽障碍患者共计90例,以随机数字表法分为观察组、对照组,各45例。对照组采用常规疗法,观察组联合通督益脑化痰汤、头项针治疗,两组均连续治疗4周。比较两组在治疗4周后的临床疗效、标准吞咽功能评估量表(standardized swallowing assessment,SSA)、功能性经口摄食量表(functional oral intake scale,FOIS)和吞咽生存质量问卷(swallow quality-of-life questionnaire,SWAL-QOL)评分,以及前白蛋白(prealbumin,PA)、白蛋白(albumin,ALB)、血红蛋白(hemoglobin,Hb)水平和大脑前动脉(anterior cerebral artery,ACA)、大脑中动脉(middle cerebral artery,MCA)、大脑后动脉(posterior cerebral artery,PCA)的平均血流速度。结果 治疗4周后,观察组的总有效率比对照组更高(P <0.05);两组的SSA评分较治疗前降低,FOIS和SWAL-QOL评分升高(P <0.05),且观察组的SSA评分比对照组更低,FOIS评分和SWALQOL评分更高(P <0.05);两组的PA、ALB和Hb水平高于治疗前(P <0.05),且观察组的PA、ALB和Hb水平比对照组更高(P <0.05);两组的MCA、ACA及PCA平均血流速度快于治疗前(P <0.05),且观察组的ACA、MCA及PCA平均血流速度比对照组更快(P <0.05)。结论 在脑卒中后吞咽障碍患者中采用通督益脑化痰汤联合头项针治疗的效果可靠,具有较好的临床应用价值。

     

    Abstract: Objective To investigate the therapeutic effect of Tongdu Yinao Huatan decoction combined with scalp and neck acupuncture in the treatment of dysphagia after stroke. Methods A total of 90 patients with dysphagia after stroke treated in Jinhua People’s Hospital from January 2023 to July 2024 were randomly assigned to an observation group and a control group, with 45 patients in each group, using a random number table method. The control group was treated with conventional therapy, while the observation group was treated with Tongdu Yinao Huatan decoction combined with scalp and neck acupuncture. Both groups were treated for four consecutive weeks. Clinical efficacy, standardized swallowing assessment(SSA) scores, functional oral intake scale(FOIS) scores, swallowing quality of life questionnaire(SWAL-QOL) scores, as well as levels of prealbumin(PA), albumin(ALB), hemoglobin(Hb), and the mean blood flow velocity of the anterior cerebral artery(ACA), middle cerebral artery(MCA), and posterior cerebral artery(PCA) were compared between two groups after four weeks of treatment. Results After four weeks of treatment, the total effective rate in the observation group was higher than that in the control group(P < 0.05). The SSA scores decreased, while the FOIS and SWAL-QOL scores increased in both groups compared to baseline(P < 0.05). The SSA scores of the observation group were lower than those of the control group, while the FOIS scores and SWAL-QOL scores were higher(P < 0.05). The levels of PA, ALB and Hb in both groups were higher than those before treatment (P<0.05),and the levels of PA,ALB,and Hb in the observation group were higher than those in the control group (P<0.05).The mean blood flow velocities of MCA,ACA and PCA in both groups were faster than those before treatment (P<0.05),and the mean blood flow velocities of ACA,MCA and PCA in the observation group were faster than those in the control group (P<0.05). Conclusion For patients with dysphagia after stroke,the combination of Tongdu Yinao Huatan decoction and scalp and neck acupuncture is obviously effective and has good clinical application value.

     

/

返回文章
返回