Abstract: Objective To investigate the effect of ciprofol for anesthesia induction on respiratory and circulatory parameters, stress response, and immune function in patients undergoing interventional embolization for cerebral aneurysms. Methods A total of 106 patients scheduled for interventional embolization of cerebral aneurysms at Nanjing Brain Hospital from January 2024 to January 2025 were enrolled and randomly divided into two groups using a random number table method. In the ciprofol group (n= 53), patients received ciprofol for anesthesia induction, while in the control group (n= 53), patients received propofol medium/long-chain fat emulsion. Changes in respiratory and circulatory parameters, stress response and immune function markers, as well as anesthesia recovery, were recorded and compared between the two groups. Results No significant fluctuations in respiratory and circulatory parameters were observed in the ciprofol group (P ＞ 0.05). In the control group, oxygen saturation (SpO₂) and mean arterial pressure (MAP) at 10 minutes after induction and 30 minutes after surgery onset were lower than those before induction and lower than those in the ciprofol group, while heart rate (HR) was higher (P ＜ 0.05). At 10 minutes post-induction, systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the control group were also lower than pre-induction levels and those in the ciprofol group. At 30 minutes after surgery onset, both SBP and DBP in the control group were higher than pre-induction values and those in the ciprofol group (P ＜ 0.05). The time to spontaneous respiration recovery, eye opening, and extubation were earlier in the ciprofol group than in the control group, and the post-anesthesia care unit stay was shorter (P ＜ 0.05). At the end of surgery, both groups showed reductions in superoxide dismutase, catalase, glutathione peroxidase, as well as CD3⁺, CD4⁺ levels and the CD4⁺/CD8⁺ ratio compared to pre-induction levels (P ＜ 0.05), but these values were higher in the ciprofol group than in the control group (P ＜ 0.05). Conclusion Compared with propofol, using ciprofol for anesthesia induction in cerebral aneurysm embolization can more effectively maintain intraoperative respiratory and circulatory stability, reduce fluctuations in stress and immune function, and provide better quality of recovery.