Abstract: Objective To investigate the clinical efficacy of low molecular weight heparin（LMWH）combined with intravenous nutrition in the treatment of fetal growth restriction (FGR) and its effect on ultrasound parameters. Methods A total of 86 pregnant women with FGR who received treatment and delivered infants at Hebi People's Hospital from December 2020 to December 2024 were enrolled. Among them, 43 patients in the intervention group received LMWH combined with intravenous nutrition, while 43 patients in the control group received intravenous nutrition alone. Maternal and neonatal indicators were compared between the two groups after 3 weeks of treatment and after delivery. Results After 3 weeks of treatment, the fetal growth parameters (head circumference, abdominal circumference, femur length, and biparietal diameter) in both groups increased (P < 0.05), and these growth parameters in the intervention group were significantly greater than those in the control group (P < 0.05). After 3 weeks of treatment, the umbilical artery blood flow parameters in both groups decreased compared with before treatment (P < 0.05), and systolic/diastolic velocity ratio (S/D ratio), resistance index, and pulsatility index in the intervention group were significantly lower than those in the control group (P < 0.05). The intervention group showed significantly higher birth weight and heavier placental weight, higher Apgar scores, and longer gestational age at delivery than the control group (P < 0.05). No statistically significant difference was observed in the cesarean section rate between the two groups (P > 0.05). The overall incidence of neonatal adverse events in the intervention group was significantly lower than that in the control group (P < 0.05). Conclusion LMWH combined with intravenous nutrition demonstrates favorable clinical efficacy in the treatment of FGR, promoting fetal growth and development, improving ultrasound parameters, and contributing to better maternal and neonatal outcomes.