Abstract: Organic/inorganic nanohybrids drug delivery system based on polymer materials is a kind of nanohybrid prepared from organic polymer materials and inorganic nanoparticles for drug delivery, which show various advantages such as easy modifiability, high targetability, remarkable stability and good biocompatibility. The organic/inorganic nanohybrids have attracted much attention for their outstanding synergistic therapeutic effects, and their application in the integration of diagnosis and therapy provides new ideas and methods for anti-tumor therapy. This article reviews the preparation strategies and applications of organic/inorganic nanohybrids, and discusses their advantages and challenges in anti-tumor therapy, so as to provide reference for further application of organic/inorganic nanohybrids.