Abstract: Based on the papers published on international and domestic journals by Chinese researchers in 2016, this review summarized the latest research advances of drug targets for a variety of major diseases, including neurodegenerative diseases (Alzheimer' s disease, Parkinson' s disease, etc.), cerebrovascular diseases, nerve disorders, cardiovascular diseases (hypertension, angina pectoris, heart failure, atherosclerosis, etc.), metabolic diseases (diabetes, fatty liver, obesity, etc.), infectious diseases, autoimmune diseases, and tumors. It provided reference and basis for drug target research in the future.