创新链/学科链/研发链/产业链

新药研发前沿动态 / 医药领域趋势进展

成纤维细胞生长因子在神经损伤修复中作用的研究进展

Research Progress in the Effect of Fibroblast Growth Factors on the Recovery of Nerve Injury

  • 摘要: 成纤维细胞生长因子具有广泛的生物学作用,影响多种细胞的生长、增殖和分化,如血管内皮细胞、成纤维细胞、神经元和星形胶质细胞等,参与生长发育和组织损伤等正常生理和病理修复过程。目前,已有大量研究阐明部分成纤维细胞生长因子具有促进脊髓损伤、外周神经损伤、脑外伤和新生儿缺血缺氧性脑损伤等神经损伤修复的功能。综述成纤维细胞生长因子在神经损伤修复中的作用及相关机制等的研究进展。

     

    Abstract: With extensive biological activities, fibroblast growth factors (FGFs) affect the growth, proliferation and differentiation of a variety of cells, such as vascular endothelial cells, fibroblasts, neurons and astrocytes and are involved in various physiological and pathological repair processes such as growth and development as well as the repair of tissue injury and nerve injury. Currently, a lot of studies have revealed that some FGFs can promote the recovery of nerve injury, such as spinal cord injury, peripheral nerve injury, traumatic brain injury and neonatal hypoxic-ischaemic brain injury. In this paper, the role of FGFs in the recovery of nerve injury and related mechanisms were reviewed.

     

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