Abstract: Currently, the antidiabetic drug market has become the second largest drug market only to that of anti-tumor drugs. There are many types of antidiabetic drugs on the market. In addition to the dominant insulin and its analogues and traditional drugs such as α-glucosidase inhibitors, sulfonylureas, biguanides and glinides, new target antidiabetic drugs such as GLP-1 agonists, DPP Ⅳ inhibitors and SGLT-2 inhibitors have also been widely used clinically in recent years and have become a hot spot on the market. This paper summarizes the global sales of antidiabetic drugs in the past 5 years, and highlights the market trend of GLP-1 receptor agonists, DPPⅣinhibitors and SGLT-2 inhibitors, in order to provide reference for antidiabetic drug innovation in China.